Thiazolidinedione moiety serves as a boon in the antidiabetic therapy by increasing the sensitivity towards insulin. 1, 3-thiazolidine-2, 4-dione contains basic skeleton of thiazole or thiazolidine. Presence of carbonyl groups at 2 and 4 positions makes it thiazolidine-2, 4-dione which is basically known for its antidiabetic activity. Objective of this research was to investigate a series of five new synthesized 1, 3 thiazolidine 2,4-dione derivatives for their antidiabetic activity by alloxan induced diabetic model in male wistar rats. Structures of synthesized compounds were confirmed by chromatographic and spectral analysis. The anti-diabetic activity of five new 2, 4-thiazolidinedione derivatives in Alloxan (120 mg/kg) induced diabetic male wistar rats were evaluated by assessing blood glucose, lipid profile, glycosylated haemoglobin and serum insulin. The findings of the present study suggest that 1, 3 thiazolidine 2, 4-dione derivatives produced significant (p<0.05) antidiabetic activity in alloxan induced diabetic rat which is comparable to glibenclamide.
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